Una O’Doherty, MD, PhD
Professor, Pathology and Laboratory Medicine

Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania

“The HIV Reservoir Is Neither Stable nor Invisible”

Friday, April 5, 2019
Noon – 1 p.m. CT
Stonewall Conference Rooms
625 N Michigan Ave
Chicago, IL 60611

Dr. Una O’Doherty is a Professor and an Apheresis Physician in the Division of Transfusion Medicine and Therapeutic Pathology at the University of Pennsylvania. Dr. O’Doherty studies how treatment resistant reservoirs of HIV are formed and maintained in HIV infected individuals. In the process of these studies, her group discovered that latent infection is favored when T cells in the quiescent state are infected without activation.  Over several years her group showed that directly infected T cells provide a model for the treatment resistant reservoir. This in vitro work led to discoveries which implied that reservoir persistence was not simply controlled by its visibility. Her current work focuses on selection pressures in vivo in a small cohort of individuals chronically infected with HIV and maintained on antiviral therapy.  By performing massive proviral sequencing on banked samples from this cohort over time, her group elucidated the presence of two opposing selective forces in vivo that appear to be driven in part by transcription.

 

 

 

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2019/04/05—Una O'Doherty, MD, PhD—"The HIV Reservoir Is Neither Stable nor Invisible"
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