Viral Pathogenesis Core


Thomas J. Hope, PhD, Northwestern University
Viral Pathogenesis Core Director

Internal Advisory Committee

Laimonis Laimins, PhD, Northwestern University
Rex L. Chisholm, PhD, Northwestern University
Mojgan Naghavi, PhD, Northwestern University

Scientific Agenda

The Viral Pathogenesis (VP) Core seeks to make the tools of modern biological HIV research accessible to the Third Coast CFAR team to facilitate collaborations between biomedical and behavioral researchers, particularly new researchers.

Services and Resources

Virology Methods and Assays

The Viral Pathogenesis Core facilitates leverages resources to provide cost-efficient, fee-for-service assays and methods of virology including virus quantification by ELISA and PCR.

Genomic Services

Members may access up-to-date next generation sequencing platforms and analyses to facilitate translational HIV research.

Laboratory Infrastructure and Viral Stock

Access to a variety of virology infrastructure and lab needs are available from the VP Core, including the BLS2+ facility, associated training, a characterized viral stock bank, and cell and tissue banks.

Virology Consultation

The VP Core offers a consultation service designed to provide insight and expertise in the design of biological experiments and choice of assays, including recommendations on a choice of reagents including cell lines, virus isolates, assays for quantification, and conditions of the experiment. Consultants will direct members to the appropriate use of the aforementioned laboratory infrastructure and banks.

Training in World Class Imaging Facilities

The VP Core’s imaging facility is a mecca for international researchers seeking training in four Delta vision deconvolution microscope systems, OMX structured illumination-based (SIM) super resolution system, a general use fluorescence microscope with three cameras and microinjection capabilities, all of which are available to Third Coast CFAR members.

Viral Pathogenesis Journal Club

The VP Core invites researchers and research trainees to join in lively, interactive critical assessment and discussion of recent peer-reviewed papers that focus on topics including, but not limited to, HIV-related virology, immunology, pathogenesis, treatment, and vaccine design. Please contact Dr. Ann Carias to join the Journal Club mailing list. The Viral Pathogenesis Journal Club meets on the first and third Monday of each month. The Third Coast CFAR provides lunch the first Monday of each month.