March, 2017

201713mar12:00 pm1:00 pmMojgan Naghavi, PhDNovel insights into HIV-1 neuropathogenesis

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Mojgan Naghavi, PhD
Associate Professor in Microbiology-Immunology

Dr. Naghavi’s research has had a long-term focus on host factors that regulate HIV-1 infection in a variety of cell types, including microglia and primary neurons. Early work discovered that the neuronal protein FEZ-1 regulates early HIV-1 infection. She has since gone on to show that FEZ1 acts as a microtubule (MT) motor adaptor protein that associates with HIV-1 capsids and regulates inward movement of viral particles to the nucleus. Dr. Naghavi have also uncovered fundamental aspects of how HIV-1 regulates MT behavior to facilitate infection and the host factors involved. This includes MT plus-end binding proteins and actin-MT cross-linkers involved in initiating virus transport. Moreover, She discovered that HIV-1 infection was regulated by PDZD8, a poorly understood protein whose biological function was unknown prior to her discovery of its role in regulating MT stability. Beyond HIV-1, Dr. Naghavi has also discovered how neurotropic viruses such as Herpes Simplex Virus type 1 (HSV-1) exploit MTs to facilitate their replication.


March 13, 2017 12:00 pm - 1:00 pm(GMT+00:00)


Northwestern University

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