Inter-CFAR HIV/TB Working Group webinar with Emily Wong, MD

Friday, July 26, 2019
12:00 p.m. CT / 1:00 p.m. ET

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Anyone interested in joining the Inter-CFAR HIV/TB working group should email Greg Bisson (bisson@pennmedicine.upenn.edu), which will also ensure that they receive future call and webinar information and Zoom call login info.

Engi Attia, MPH, MD
Assistant Professor
University of Washington)

HIV/AIDS-related HLBS Research Webinar Series

“Chronic Lung Disease among Adolescents Living with HIV: Insights from Kenya and the U.S.”

Wednesday, April 10, 2019
11 a.m.- 12 p.m. Central Time

Engi Attia, MPH, MD is the current presenters for the NHLBI HIV/AIDS-related heart, lung, blood, and sleep (HLBS) research webinar series. This program serves to highlight state of the art research from experts in the field and provide a platform for disseminating pertinent NHLBI HIV/AIDS-related research announcements. There will also be a short Q&A session to discuss upcoming NHLBI HIV/AIDS funding opportunities.

You may register for the webinar here.

Sumit Chanda, PhD
Director and Professor
Immunity and Pathogenesis
Program Sanford Burnham Prebys Medical Discovery Institute

“Systems-level Analysis of HIV-Host Interactions”

Monday, April 8, 2019
Noon – 1 p.m. CT
Stonewall Conference Rooms
625 N Michigan Ave
Chicago, IL 60611

Sumit Chanda earned his Ph.D. from Stanford University in 2001, and received his post-doctoral training at the Genomics Institute of the Novartis Research Foundation (GNF). He subsequently transitioned to a Group Leader position, and established his research group in the Division of Cellular Genomics at GNF. In 2007, he joined the Infectious and Inflammatory Disease Center at Sanford-Burnham Medical Research Institute as an Associate Professor. Dr. Chanda also holds an Adjunct Professor appointment at the Salk Institute for Biological Studies, as well as a Visiting Scientist position at the Genomics Institute of the Novartis Research Foundation.

RSVP Here:

Una O’Doherty, MD, PhD
Professor, Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania

“The HIV Reservoir Is Neither Stable nor Invisible”

Friday, April 5, 2019
Noon – 1 p.m. CT
Stonewall Conference Rooms
625 N Michigan Ave
Chicago, IL 60611

Dr. Una O’Doherty is a Professor and an Apheresis Physician in the Division of Transfusion Medicine and Therapeutic Pathology at the University of Pennsylvania. Dr. O’Doherty studies how treatment resistant reservoirs of HIV are formed and maintained in HIV infected individuals. In the process of these studies, her group discovered that latent infection is favored when T cells in the quiescent state are infected without activation.  Over several years her group showed that directly infected T cells provide a model for the treatment resistant reservoir. This in vitro work led to discoveries which implied that reservoir persistence was not simply controlled by its visibility. Her current work focuses on selection pressures in vivo in a small cohort of individuals chronically infected with HIV and maintained on antiviral therapy.  By performing massive proviral sequencing on banked samples from this cohort over time, her group elucidated the presence of two opposing selective forces in vivo that appear to be driven in part by transcription.

RSVP Here:

Nanette Benbow, MAS, BSIS Core Co-Director, will join Alan Greenberg, MD, MPH (DC CFAR) and April Petit MD, MPH (Tennessee CFAR), in an inter-CFAR webinar detailing successful partnerships between CFAR investigators and public health departments.

The University of North Carolina Center for AIDS Research (UNC-CFAR) hosts the inter-CFAR webinar series.

You may register for the webinar here.

Date/Time: Wednesday, March 20, 2019; from 1:00pm – 2:00pm (CST)

Speaker: Michael Busch, MD, PhD (Professor at UCSF; Director of Vitalant Research Institute)

Title: Effects of Early ART and PrEP on HIV Diagnostics and Donor Screening

Registration Link: goo.gl/UHrqnh

Michael Busch, MD, PhD is the current presenter for the NHLBI HIV/AIDS-related heart, lung, blood, and sleep (HLBS) research webinar series. This program serves to highlight state of the art research from experts in the field and provide a platform for disseminating pertinent NHLBI HIV/AIDS-related research announcements. There will also be a short Q&A session to discuss upcoming NHLBI HIV/AIDS funding opportunities.

In 1999, a man came into San Francisco City Clinic and was diagnosed with syphilis. He had had sex with many men but didn’t know their names, although they were all members of the same SF-based AOL chat room. The rest is history. From early interventions such as inSPOT, online partner notification, to modern mobile apps and social media, digital programs continue to show much promise in stemming the tide of the epidemic.

In this talk, Deb will cover early digital HIV prevention program development in concert with the SF community, evidence-based studies and literature reviews, and how-tos for more recent work on social media sites like Snapchat and Instagram.

Deb Levine, BSW, MA is the Founder and Former Executive Director of YTH (youth+tech+health) from 2001-2014. Currently, she is the Principal at her new consulting company, Tech Strategy Consultants. She has won many awards for her work in digital health for youth, including a White House – HHS award for a mobile app for college students, and a citation in former President Clinton’s report on Education and the Internet for her ground-breaking work on Columbia University’s Go Ask Alice. She has degrees from Cornell University and New York University, and is raising two teenagers in Oakland, CA.

This event is Co-sponsored with the The Institute for Sexual and Gender Minority Health and Wellbeing (ISGMH).

Please RSVP Here. 

Institute for Public Health and Medicine Seminar Series:

“Bridging the Knowledge and Quality Gap: Using Implementation Research in Global Health to Accelerate Change (and how Rwanda succeeded in reducing child mortality)”

Lisa R. Hirschhorn, MD, MPH
Professor of Medical Social Sciences, and Psychiatry and Behavioral Sciences
Northwestern University Feinberg School of Medicine

Join the Institute for Public Health and Medicine for engaging speakers on relevant research in public health. CME credit is available for most seminars. Lunch is provided on a first-come, first served basis.

Details are subject to change. The latest information can be found on the Seminar Series webpage: feinberg.northwestern.edu/sites/ipham/events

Dr. Jessica Ridgway and Professor Rayid Ghani will present the results of their projects funded by CFAR Pilot awards. These projects funded by CFAR will focus on the HIV-related predictive analytics and machine learning.

“Predictive Analytics for Retention in HIV Care” 

Jessica P. Ridgway, MD, MS
Assistant Professor, Department of Medicine
Section of Infectious Diseases and Global Health
The University of Chicago

Dr. Ridgway is the Director of Predictive Analytics for the Chicago Center for HIV Elimination at the University of Chicago and her research focuses on the use of informatics and predictive analytics to improve HIV treatment and prevention. She is particularly interested in how electronic medical record data can be harnessed to improve HIV prevention and care across the HIV care continuum.

“Combining Human Knowledge and Machine Learning to Increase Retention in Care for HIV Patients” 

Rayid Ghani
Research Associate Professor, Department of Computer Science 
Senior Fellow, Harris School of Public Policy 
Director, Center for Data Science and Public Policy 
The University of Chicago

Professor Rayid Ghani is the Director of the Center for Data Science and Public Policy, Research Director and Senior Fellow at the Computation Institute, and a Senior Fellow at the Harris School of Public Policy at the University of Chicago. Ghani’s work has spanned from general machine learning and data science to privacy preserving data analysis, text analysis, semi-supervised learning, active learning, information retrieval, Natural Language Processing, and knowledge management. Most of Ghani’s work has focused on developing and using machine learning & data mining approaches to solve large-scale problems in corporate, political, and non-profit areas.

Grand Rounds Conference

8:00 am-9:00 am

Prentice, 3rd floor, Canning Auditorium

Presented by:  

Sharlay Kimberly Butler, MD

Fourth Year Resident

Department of Obstetrics and Gynecology

Northwestern University

Francois Villinger, DVM
Professor,Department of Biology 
Director, New Iberia Research Center
University of Louisiana at Lafayette

Dr. François Villinger is a DVM from the University of Zurich, with over 30 years of research in infectious diseases, vaccines and immune responses using Nonhuman primate models of human diseases. Before taking the lead at the New Iberia Research Center in late 2015, he was a Professor of Pathology at the Emory School of Medicine and Associate Director for Pathology at the Yerkes National Primate Research Center in Atlanta. His main research focus has been on HIV models, and the development of tools and reagents specific for nonhuman primate investigations. Recently he has spearheaded a whole body to single cell analysis of immune mechanisms and viral dynamics in real time.

The 2019 Miami Winter Symposium,“Evolving Concepts In HIV & Emerging Viral Infections”, will be held on January 27 –30, 2019.  The deadline for abstract submission is October 19, 2018. More information can be found at  www.miamiwintersymposium.com

Stephanie Masiello Schuette, PhD
Director of Program Operations
HIV/STI Surveillance, Epidemiology, and Research
Chicago Department of Public Health

Dr. Schuette will present recent findings from the CDPH 2018 HIV / STI Surveillance Report and provide new insight into the HIV epidemic in Chicago.

Drs. Joshua Leonard and Chisu Song will present the results of their Third Coast CFAR pilot projects.

“Engineered extracellular vesicle-mediated delivery of targeted nucleases to inactivate HIV proviral DNA”

Joshua L. Leonard, PhD
Associate Professor
Chemical and Biological Engineering
Northwestern University McCormick School of Engineering

Joshua L. Leonard, PhD is an Associate Professor of Chemical and Biological Enginering at Northwestern University McCormick School of Engineering. His research group works at the interface of systems biology and synthetic biology in order to probe and program the function of complex, multicellular systems to develop transformative biotechnologies and enable a new paradigm of design-driven medicine. Using the tools of synthetic biology, biomolecular engineering, computational systems biology, and gene therapy, they develop technologies including programmable cell-based “devices,” immune therapies for cancer and chronic disease, smart vaccines, biosensors for global health applications, and tools for advanced metabolic engineering. By bringing an engineering approach to the investigation, design, and construction of biological systems, Dr. Leonard’s research group is advancing the frontiers of design-driven medicine to address unmet medical needs and create safe, effective, and long-lasting treatment options that improve both quantity and quality of life.

“Regulation of  APOBEC3 proteins: Implication for HIV and Cancer”

Chisu Song, PhD
Research Assistant Professor
Medicine, Infectious Diseases
Northwestern University Feinberg School of Medicine

Chisu Song, PhD is a research assistant professor of Medicine in the Division of Infectious Diseases at Northwestern University. Dr. Song received his doctorate at the University of Alabama in Virology in 2001. He completed his postdoctoral in microbiology and Hematology-Oncology at the University of Alabama, and Microbiology and Immunology at Vanderbilt University.

The Third Coast Center for AIDS Research will co-sponsor a seminar in Northwestern University’s Lectures in Life Sciences series

Wesley I. Sundquist, PhD

Distinguished Professor and Co-Chair 
Department of Biochemistry
University of Utah

Cellular, molecular and structural biology of HIV

Hughes Auditorium
Lurie Medical Research Center
303 E. Superior Street
Chicago Campus
Northwestern University

Wesley Sundquist, PhD is Samuels Professor and Co-Chair of the Department of Biochemistry at the University of Utah. He is also a member of the Cell Response and Regulation Program at Huntsman Cancer Institute.

Dr. Sundquist’s lab studies the cellular, molecular and structural biology of retroviruses, particularly HIV, and the roles of the ESCRT pathway in cell division and the abscission checkpoint. Major projects in our lab include studies of: 1) ESCRT pathway functions and regulation in cell division, 2) HIV budding, 3) HIV capsid structure, function and restriction, particularly by the TRIM5α system, and 4) Designed enveloped protein nanoparticles. Our approaches include NMR, EM, crystallographic and computational studies of viral complexes, identification and biochemical analyses of the interactions between viral components and their cellular partners, and genetic analyses of viral and cellular protein functions.

Putting Human Rights To Work for Global Health: Innovations in Human Rights Practices and Metrics
Friday, November 2, 2018
9 – 1 p.m.
Regenstein Library, Room 122
1100 E. 57th St, Chicago, IL

This half-day workshop reviews human rights-based interventions in a variety of settings and with a variety of vulnerable populations. Speaker will provide an overview of their experience with human rights-based approaches, with special attention to major programmatic successes or failures, and to innovations in program implementation and/or outcomes measures. Light breakfast and lunch will be served. Register at humanrights.uchicago.edu.  You may contact Ashley Pierce at human-rights@uchicago.edu.

Special Guest Speaker: Deborah L. Birx, MD
US AIDS/HIV Ambassador and
Special Representative for Global Health Diplomacy

Renslow Sherer, MD
University of Chicago

David Munar, CEO
Howard Brown Health

Alice Kim, MA, MFA
Director of Human Rights Practice,
Pozen Family Center for Human Rights

Evan Lyon, MD
Medical Director, Heartland Health Outreach

Brian Citro, JD
Northwestern University School of Law

Symposium Overview

Join us for the Annual Third Coast CFAR Symposium Ending the HIV Epidemic: Think Globally, Act Locally. This multidisciplinary symposium will draw important connections between HIV research in global settings and the lessons researchers can apply to their domestic work. Examples of the “global to local” approach will include innovations in HIV testing, prevention and care, as well as implementation science approaches to scale up of new interventions, and the role of research on non-communicable diseases and HIV.

Symposium Information

The Annual Third Coast CFAR Symposium, Ending the HIV Epidemic: Think Globally, Act Locally, will take place at the Gordon Center for Integrative Science on Thursday, November 1, 2018.

Announcement for registration and call for abstracts to be released in August 2018.

Third Coast Center for AIDS Research
625 N Michigan Ave.
Suite 1400
Chicago, IL 60611

Gordon Center for Integrative Science
The University of Chicago
929 E. 57^th Street
Chicago, IL 60637

Lena Al-Harthi, PhD
Professor and Acting Chair
Department of Microbial Pathogens and Immunity
Rush Medical College

Lena Al-Harthi, PhD is a professor and acting chair in the Department of Microbial Pathogens and Immunity. She is also the program director of the Rush Initiative to Maximize Student Development, or Rush-IMSD, an NIH-funded training grant for underrepresented minority PhD students enrolled in the PhD in Integrated Biomedical Sciences program in the Graduate College. Her dissertation research was conducted as an NIH pre-intramural research training fellow at the laboratory of tumor cell biology, headed by Robert Gallo, MD, a co-discoverer of HIV and under the mentorship of Suresh Arya, PhD. Her research is focused on understanding mechanism(s) driving HIV neurocognitive disorders (HAND) and HIV latency in the central nervous system. Specifically, she studies the role of astrocytes in HAND and HIV latency. Al-Harthi has more than 80 peer-reviewed publications and reviews and has given many invited talks worldwide relating to HIV pathogenesis, especially in the central nervous system.

Judith S. Currier, MD, MSc
Professor of Medicine Chief, Division of Infectious Diseases
Co-Director Center for AIDS Research and Education Center (CARE)
Department of Medicine University of California, Los Angeles (UCLA)

Cardiovascular Disease in HIV: Mechanisms and Potential Interventions

Monday, October 22, 2018
Noon – 1 p.m.
Stonewall Conference Rooms
625 N Michigan Ave
Chicago, IL 60611

Dr. Currier is Professor of Medicine and Chief of the Division of Infectious Diseases and Co-Director of the Center for AIDS Research and Education Center (CARE) in the Department of Medicine at University of California, Los Angeles (UCLA). She is Chair of the NIH sponsored AIDS Clinical Trials Group. Her research has focused on HIV therapeutics and long-term complications of HIV disease with an emphasis on sex differences and antiretroviral therapy, cardiovascular disease, and women’s health.

The 2019 Miami Winter Symposium,“Evolving Concepts In HIV & Emerging Viral Infections”, will be held on January 27 –30, 2019.  The deadline for abstract submission is October 19, 2018. More information can be found at  www.miamiwintersymposium.com

J.D. Smith, PhD and Nanette Benbow, MAS will identify the proportion and characteristics of HIV-related implementation research studies funded by NIH, discuss multiple implementation research methods used to study interventions targeting various points in the HIV prevention and care continuums, and present potential opportunities for next steps. If you would like consultation in implementation science methods or research, please contact the Third Coast CFAR’s Behavioral, Social, and Implementation Sciences (BSIS) core by emailing cfar@northwestern.edu.

J.D. Smith, PhD
Assistant Professor
Department of Psychiatry and Behavioral Sciences and Preventative Medicine
Associate Director
Center for Prevention Implementation Methodology (Ce-PIM)
Northwestern University Feinberg School of Medicine

 Nanette Benbow, MAS
Research Assistant Professor
Department of Psychiatry and Behavioral Sciences 
Northwestern University Feinberg School of Medicine

Nanette Benbow, MAS is a research assistant professor in the Department of Psychiatry and Behavioral Sciences at the Northwestern University Feinberg School of Medicine; Director of the Third Coast Center for AIDS Research End HIV Scientific Working Group; and member of the Center for Prevention Implementation Methodology. Her research interests include the use of epidemiologic and network modeling to improve HIV prevention and care continua; health equity for Latinos and sexual and gender minorities; and developing academic-public health partnerships in implementing evidence-based interventions that reduce HIV incidence in local settings. Before joining the Northwestern Faculty in 2016, Ms. Benbow was deputy commissioner of the STI/HIV Services Bureau of the Chicago Department of Public Health (CDPH) where she oversaw the development and implementation of prevention and care interventions.

George J. Greene, Ph.D., (he/him) is the associate director of the Evaluation, Data Integration, and Technical Assistance Program (EDIT) and faculty in the Department of Medical Social Sciences at Northwestern University. Dr. Greene’s research interests focus on health disparities in lesbian, gay, bisexual, and transgender (LGBT) adolescents and young adults, with a particular emphasis on ethnic/racial disparities in the HIV epidemic. His research aims to: (a) understand HIV risk and protective factors from intersectionality and developmental-ecological perspectives; (b) employ community-based participatory research approaches to build upon the needs and strengths of communities to identify and develop effective interventions; (c) design technology- and Internet-based approaches for observation and intervention; (d) adopt theoretically-driven program evaluation approaches to appropriately evaluate HIV prevention research and service efforts; and (e) apply qualitative and mixed methods approaches to research and program evaluation efforts

Midwest LGBTQ Health Symposium

The 2018 Midwest LGBTQ Health Symposium (MLHS) will explore this year’s theme “Moving Towards Health Equity. Strengthening our Community of Care.” The two-day gathering of healthcare professionals, social service providers, advocates, and researchers will highlight innovative best practices in LGBTQ patient-centered clinical care as well as community-driven approaches to addressing health disparities. Join us as we explore these critical topics and others – HIV elimination, racial equity in LGBTQ care, addressing violence and reproductive justice, as providers and advocates striving for meaningful change. Third Coast Center for AIDS Research is a2018 sponsor of the event.

The Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) will host the IAS pre-conference on Sunday, July 22 from 12:00 to 2:00 PM CET (UTC+1:00).
C3PNO, the data coordinating center for the National Institute on Drug Abuse (NIDA) longitudinal HIV cohorts, will demo the new C3PNO virtual repository which links laboratory, clinical, and biological data (i.e., blood and guts) with substance use and behavioral outcomes (i.e., glory).

Date: Sunday, July 22, 2018 – Lunch provided for registrants
Time: 12:00-2:00 PM (CET, UTC+1:00)
Room: E103

Agenda:
• Introductory comments from Redonna Chandler, PhD – NIDA AIDS Research Program Director
• C3PNO Overview
• Cutting-edge C3PNO cohort science
• Case study: combining cohort data to understand the opioid epidemic in sentinel populations
• Using the virtual repository
• Data linking initiatives including depression among cohort participants
• Pilot projects
• New collaborations

RSVPs: https://goo.gl/forms/5sJbGfQpVNYFYLLC3

About C3PNO: Our mission is to stimulate research and encourage new collaborations studying substance use in the context of HIV pathogenesis. C3PNO fosters cutting-edge science powered by the cohorts’ combined sample size of over 12,000 participants. These cohorts span North America and some, like ALIVE and VIDUS, reach back over 25 years. The cohorts include injecting drug users, men who have sex with men, and clinically-based populations. Participating cohorts include ACCESS, ALIVE, HYM, Johns Hopkins HIV Clinical Cohort, the John Hopkins Heart Study, MASH, mSTUDY, RADAR, and VIDUS.

C3PNO is led by co-Principal Investigators Pamina Gorbach, DrPH, MHS (University of California Los Angles) and Suzanne Siminski, MS, MBA (Frontier Science).

Learn more about C3PNO by going to www.c3pno.org or contacting aeragsdale@mednet.ucla.edu.

*Accepting Applications through Tuesday, June 12, 2018*

The Office of Behavioral and Social Sciences Research (OBSSR) in coordination with a number of National Institutes of Health (NIH) Institutes and Centers and the U.S. Department of Veterans Affairs (VA), are hosting this training institute to provide participants with a thorough grounding in conducting D&I research in health across all areas of health and health care. In 2018, the institute will utilize a combination of a 4-month online course (six modules with related assignments) between August 13 and November 30 , 2018, and a 2-day in-person training to be held December 6-7, 2018, in Bethesda, MD. Faculty and guest lecturers will consist of leading experts in theory, implementation, and evaluation approaches to D&I; creating partnerships and multilevel, transdisciplinary research teams; research design, methods, and analyses appropriate for D&I; and conducting research at different and multiple levels of intervention (e.g., clinical, community, policy).

Participants will be expected to return to their home institutions prepared to share what they have learned at the institute to help further the field of D&I research (e.g., giving talks, leading seminars, forming new collaborations, mentoring, submitting D&I grant proposals, etc.).

For more information, and to apply, visit the TIDIRH Website.

Drs. Hossein Ardehali and Matthew J. Feinstein will present the results of their Third Coast CFAR pilot projects.

“HIV and Diastolic Dysfunction”

Hossein Ardehali, MD, PhD
Director
Feinberg Cardiovascular and Renal Research Institute –
Center for Molecular Cardiology
Professor
Medicine (Cardiology) and Pharmacology
Northwestern University Feinberg School of Medicine

Dr. Hossein Ardehali, professor of Medicine in the Division of Cardiology and of Pharmacology, leads a lab committed to investigating the role of mitochondria and cellular metabolism in cardiovascular disease. As director of the Center for Molecular Cardiology at the Feinberg Cardiovascular Research Institute (FCVRI), he also supports overall research efforts in molecular cardiology throughout the medical school.

“Causes and Characteristics of Cardiac Dysfunction and Heart Failure in HIV”

Matthew J. Feinstein, MD, MS
Assistant Professor
Medicine and Preventive Medicine Division of Cardiology
Northwestern University Feinberg School of Medicine

Dr. Matthew Feinstein is a cardiologist at Northwestern Medicine and an assistant professor at the Northwestern University Feinberg School of Medicine with a dual appointment in the Department of Medicine and Department of Preventive Medicine. Dr. Feinstein is a physician-scientist with expertise in the epidemiology and prevention of cardiovascular diseases as well as cardiovascular complications of human immunodeficiency virus (HIV) and chronic inflammatory diseases.

Xu Yu, MD

Associate Professor 
Harvard Medical School

Xu Yu, MD is the current presenter for the NHLBI HIV/AIDS-related heart, lung, blood, and sleep (HLBS) research webinar series. This program serves to highlight state of the art research from experts in the field and provide a platform for disseminating pertinent NHLBI HIV/AIDS-related research announcements. There will also be a short Q&A session to discuss upcoming NHLBI HIV/AIDS funding opportunities.

You may register for the webinar here.