NIH CFAR Administrative Supplements – FY2021

Funding Opportunity Description

The NIH has released a Request for Applications (RFA) for administrative supplements to Center for AIDS Research (CFAR) P30 grants, including the Third Coast CFAR. Supplements will be competitively funded to support innovative, short-duration (10 month) research projects consistent with NIH HIV research priorities (NOT-OD-20-018), and that will generate pilot data for a subsequent NIH grant application. Applications are due at NIH on April 19, with internal budget and subcontract deadlines as early as late March.

The Third Coast CFAR will have an internal competition to choose the supplement applications that can be submitted to NIH in April. Internal proposals are due to the Third Coast CFAR on Thursday, February 25 by 11:59 p.m. Potential applicants are encouraged to contact the Developmental Core as soon as possible to discuss their project idea and team.

Areas of Interest

  1. Uptake and retention for long-acting HIV prevention and treatment
  2. Interactions and effects of the microbiome and metabolome on comorbidities and co-infections in people with HIV
  3. Disparities in Treatment and Outcomes in People with HIV with multiple comorbidities and co-infections 
  4. Impact of HIV infection and HIV-associated comorbidities, coinfections and complications on hemophiliacs and the hematopoietic system 
  5. Intersectional Stigma and its Effect on HIV Prevention, Treatment and Care 
  6. Increasing the Integration of Substance Abuse Services and HIV Prevention and Care 
  7. Understanding HIV Reservoir Establishment, Maintenance, Control, and Clearance 
  8. Natural History of Reservoir Establishment in Infants


Priority will be given to projects led by faculty who are new to HIV research or who have not yet received an R01 or equivalent award (i.e. P-series or U-series grant) for HIV research. Some topics specifically restrict eligibility to Early Stage Investigators (see details in the RFA). Post-doctoral fellows are eligible to apply if they will assume a faculty position by the time the supplement project and funding begins (and a letter stating that is required from their academic leadership in the application to NIH). Individuals from underrepresented racial and ethnic groups, as well as individuals with disabilities, are always encouraged to apply for NIH support.

Studies that are a continuation of previously funded CFAR supplements or funded NIH applications, and do not address new specific aims, are not eligible for funding under this announcement. Additionally, a proposal for a CFAR supplement that is linked to a submitted or pending NIH proposal is not eligible. Projects that include research with human subjects must provide an IRB approval notice or exemption determination to the Third Coast CFAR by July 1, 2021.

Funds Available and Project Period

Supplement awards are for 10 months (7/1/2021 – 4/30/2022) with maximum funding per application of up to $150,000 in direct costs, not including third party indirect costs.

Internal Proposals

If you are interested in applying for an administrative supplement, please email a one-page proposal to Justin Schmandt by 11:59 p.m. on February 25. References do not count toward the page limit. Plans are not binding, but the one-page proposal must include the following information (under each heading below):

  • Research area from RFA
  • Project leaders (names, titles, and institutions)
  • Team members (names, titles, and institutions). Team members do not have to be exclusive to one proposal and can be named on more than one proposal.
  • Mentor name (if applicant has not yet had an R01-equivalent award)
  • Working project title
  • Brief synopsis of the project
  • Preliminary plan for subsequent NIH grant application that this proposed supplement will enable
  • Plans, if any, to utilize CFAR core services
  • Plans for IRB oversight, if applicable

Download the full RFA

Developmental Core

Jenny Trinitapoli, PhD The University of Chicago
Developmental Core Director

Richard D’Aquila, MD, Northwestern University
Developmental Core Co-Director

To request information about Developmental Core awards and services, contact a research navigator.