Ending the HIV Epidemic Supplement Projects – FY22

The NIH has released a Request for Applications (RFA) for collaborative, implementation research projects that will advance the goals of the Ending the HIV Epidemic (EHE) initiative. Applications responding to this RFA will be submitted as requests for supplements to the Third Coast CFAR grant. The Third Coast CFAR will organize an internal competition to choose the applications that can be submitted to NIH in April. These one-page proposals are due to the Third Coast CFAR by February 3. Final applications are due at NIH by April 4, with internal budget and subcontract deadlines as early as the last week of February.

Eligibility and Purpose

Applicant teams must be led by a PI-eligible investigator at Northwestern University, the University of Chicago, or Lurie Children’s Hospital, in partnership with a community-based organization or public health department funded by CDC, HRSA, SAMHSA, or IHS to provide HIV services in one of the 57 jurisdictions identified in EHE. Investigators are encouraged to collaborate with researchers from historically black colleges and universities (HBCUs) and Minority Serving Institutions (MSIs).

The role of the NIH, as a research platform in the EHE initiative, is to support implementation research by addressing the four key pillars (Diagnose, Treat, Prevent, and Respond). Specifically, the NIH will support CFARs to collaborate with local partners funded by the participating HHS agencies to support local EHE plans. Several critical principles should guide these efforts, including value added for all members of the partnership, representation of people with lived experience, as well as communication and collaboration through all phases of the project. Refer to strategies for community engaged research in Sanders, et al., 2021.

Research Topics, Funds Available, and Project Period

When developing initial plans, applicants should take into consideration that award amount and project length vary by topic.

Topic 1. Planning projects to support participatory data science research efforts toward Ending the HIV Epidemic in the United States

Topic 2. Equity-focused approaches to reduce HIV-related health disparities

Topic 3. Strategic alliances across jurisdictions to reach EHE goals through implementation research 

Topic 4. Applying behavioral economic approaches to design implementation strategies for HIV testing, prevention, and care 

Topic 5. Implementation Strategies to Facilitating a Status Neutral Approach to HIV Prevention and Treatment 

Internal Proposals

If you are interested in applying for an EHE supplement, please contact Justin Schmandt as soon as possible to discuss your idea and tentative team. One-page proposals will be submitted via email by 5:00 p.m. on February 3. References do not count toward the page limit. More than one internal proposal may be submitted to the CFAR, although faculty will not be allowed to serve as PI or Co-PI on more than one final application to the NIH. Plans are not binding, but the one-page proposal must address and be organized by the points below. Please note that faculty submitting a full application to the NIH must have IRB approval for the their project by June 15. Not having IRB approval by June 15 may jeopardize funding for all supplement projects because they are awarded in a single notice.

  • Academic project leader/supplement PI (name, title, and institution)
  • Primary implementation partner (name, title, and institution)
  • Additional academic institutions or community partners (name, title and affiliation)
  • Research topic, EHE pillar/s to be addressed, and the related service or program (funded by CDC, HRSA, SAMHSA, IHS, CDPH, or IDPH)
  • Team members (names, titles, and institutions). Co-investigators and team members can be named on more than one proposal.
  • Working project title
  • Brief synopsis of the project
  • Anticipated outcome/s of the project


One-page proposals will be competitively reviewed the week of February 7. Selections will be shared as quickly as possible. The NIH will likely release the RFA for CFAR program supplements in the basic, clinical, social and behavioral sciences (i.e., not EHE supplements) near February 10. The Developmental Core will organize a separate internal competition for CFAR program supplements.

View the full RFA

Definition of Implementation Research

For the purposes of this RFA, implementation research is defined as the scientific study of the use of strategies to adopt and integrate evidence-based health interventions into clinical and community settings to improve individual outcomes and benefit population health. Implementation research therefore seeks to understand and change the behavior of practitioners and support staff, organizations, consumers and family members, and policymakers to improve the adoption, implementation, and sustainability of evidence-based health interventions and guidelines. In addition to changing behaviors, implementation research can also understand and evaluate how to modify internal/external policies or procedures, norms, or other social/structural factors that are impeding on implementing and sustaining intervention delivery. 

Studies of implementation strategies should build knowledge both on the overall effectiveness of the implementation strategies (implementation outcomes), as well as “how and why” they work (implementation mechanisms). 

Data on facilitators and barriers (implementation determinants) to program success, mechanisms of action, moderators and mediators of implementation strategies, and implementation outcomes will greatly aid decision-making on which strategies work for which interventions, in which settings, and for what populations. Applicants should therefore incorporate implementation science theories, models, and/or frameworks appropriate for implementation research to inform study hypotheses, measures, implementation outcomes, and health outcomes if able to be measured. 

Training and Other Resources

Introductory workshops and presentations on implementation research concepts and real-world examples of implementation research projects are available via the Inter-CFAR Implementation Science Working Group. Materials and training on the implementation research logic model and implementation outcomes crosswalk are also publicly available through the the Implementation Science Coordination, Consultation, and Collaboration Initiative (ISC3I).

The Third Coast CFAR’s Behavioral, Social, and Implementation Sciences (BSIS) Core and the Ending the HIV Epidemic Scientific Working Group (EHE SWG) can provide consultation as teams develop their applications. Contact a research navigator to request consultation.

Developmental Core

Jenny Trinitapoli, PhD The University of Chicago
Developmental Core Director

Richard D’Aquila, MD, Northwestern University
CFAR Director

To request information about Developmental Core awards and services, contact Justin Schmandt.