Jeremy Luban, MD
Medical Director, Nepal Orthopedic Hospital
Professor, Program in Molecular Medicine
Joint Appointment, Biochemistry and Molecular Pharmacology
University of Massachusetts School of Medicine
Worcester, Massachusetts



Mojgan Naghavi, PhD
Department of Microbiology-Immunology
Northwestern University Feinberg School of Medicine
Chicago, Illinois


Innate Immunity to HIV-1


HIV-1-infected people who take antiviral drugs that render viremia undetectable have ongoing inflammation of unknown etiology. The HIV-1 provirus, a permanent genetic element in long-lived cells of the immune system, is not eliminated by antiviral drugs, and is therefore a possible contributor to this inflammation. Our results indicate that Rev-dependent, intron-containing, HIV-1 RNA is detected by the innate immune system, and that drugs which inhibit HIV-1 transcription or Rev-dependent, HIV-1 RNA metabolism, would add qualitative benefit to current antiviral drug regimens.