Microbiology-Immunology Seminar Series

AIDS is incurable due to the stable integration of HIV DNA into cellular chromatin. Integrase, the responsible enzyme, is a high value antiviral target. Dr. Engelman`s research has helped uncover the structural basis of HIV DNA integration, as well as the mechanism of action of the clinical integrase inhibitors. He has additionally characterized a new class of integrase inhibitor that unexpectedly inhibits HIV particle maturation.

Alan Engelman, PhD

Harvard Medical School

Host: Mojgan Naghavi, PhD