We have discovered effective prevention and treatment approaches for HIV/AIDS, yet the number of new HIV infections each year in the US has remained relatively stable over more than a decade. In his talk, Dr. Mustanski will describe two hybrid effectiveness-implementation trials of HIV prevention programs for teen and young adult gay/bisexual men. He will also discuss our approach to supporting the use of implementation science in the federal initiative for Ending the HIV Epidemic in the US by 2030.